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Case study:
UV-C disinfection box

Speeding up product development: fast calibration of UV-C power and exposure on autofluorescent viruses

As an independant laboratory, we were contacted by the company Clinit Technologies to measure the efficiency of one of their product, aiming at the disinfection of small objects. We used our autofluorescent ANCHOR™ Adenovirus type 5, a non-enveloped virus displaying high resistance to disinfection processes,  which allows simple and fast monitoring of viral reduction upon UV-C exposure. Results were generated in 24h. This viral model, which is quick to set up, is therefore the most relevant for defining the necessary decontamination times and power output to achieves the best infectious virus reduction.

UV-C disinfection of an ANCHOR™ hAdV5 (Green) as a function of exposure time.

Following several rounds of product optimization, validation on a collection of viruses interest

The commercial boxes developed by Clinit technologies aimed at the disinfection of at least 5 logs of SARS-CoV-2 and maximal effect on other class of viruses. To qualify the product, we used one of our SARS-CoV-2 strain in BSL3 laboratory and measure the efficiency of the final product directly before commercial release.

Clinit technologies product achieved high level of disinfection as measured directly on live infectious viruses:

           -SARS-COV-2: >99,9998% (>5log10)

           -Influenza virus H1N1: >99,998% (>4log10)

           -hAdenovirus5: >99,99% (>4log10)

We have also a unique capacity to visualize virus infection using advanced imaging techniques. For commercial and marketing applications, we also verified the efficiency of Clinit technologies product using microscopy.  On the slider below is shown SARS-CoV-2 infection before and after disinfection with Clinit product. (blue: cell nuclei, green SARS-CoV-2 viral RNA, red: SARS-Cov-2 NP).

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After generation of a full report and a certificate of analysis for Clinit customers, Clinit Technologies e-Box UV-C irradiation system was launched on the market.

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