Orthopoxviruses ANCHOR™
Characteristics
Orthopoxviruses are large enveloped virus, with a genome consisting of linear double-stranded
DNA of 170 to 250 kilobases. Replication is strictly cytoplasmic
Pathogenicity
Pathogenic, can induce severe diseases in humans from variola virus (VARV virus eradicated in the 80s thanks to vaccination) to zoonotic monkeypox or cowpox virus..
- Antivirals : Brincidofovir, Tecovirimat, Metisazone
Fundamental research
Suitable for high content screening
Antiviral discovery
Applications
Our Vaccinia virus (VacV) is combined with our ANCHORTM technology. This allows us to easily visualize viral infection and replication in high throughput imaging, making this virus an excellent tool. VacV-ANCHOR allows the discovery or repositioning of active antiviral molecules but also fundamental research on its biology. A Cowpox-ANCHOR virus is under development.